Parents

• Richard Penn Smith (1799–1854)
• Isabella Stratton Knisell (1812–1880)

Spouses

• James E. Fleming

Siblings

• Richard Penn "Colonel" Smith Jr. (1837–?)
• William Moore Smith (1841–?)
• Eliza Arnold Smith (1841–?)
• Maria Lewis Smith (1844–1869)

Children

• Lizzie Schroder Fleming d.inf. (1860–1860)
• Williamina Fleming d.inf. (1863–1864)
• Maria Smith Fleming d.inf. (1865–1865)
• Eliza Gould Fleming d.inf. (1866–1866)
• Maria Lewis Fleming (1871–?)
• Isaac Wistar Fleming (1875–1875)

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